SubtiBank SubtiBank
Version comparison:

2017-04-09 20:19:272025-05-13 13:35:20

description

ATPase, centromere-like function involved in forespore chromosome partitioning / negative regulation of [[category|Sporulation]] initiation

locus

BSU_40970

proteinLength

253

geneLength

762

function

forespore chromosome partitioning / negative regulation of [[category|Sporulation]] initiation

product

negative regulator of [[category|Sporulation]] initiation

essential

no

names

parA

soj

spo0JA

outlinks

bsupath

parA_4206397_4207158_-1

outlinks

uniprot

P37522

outlinks

subtilist

gene_detail BG10055

outlinks

bsu

BSU_40970

genomicContext

[[this]]

categories

[[this]]

Gene

Coordinates

4,206,397 4,207,158

Gene

Phenotypes of a mutant

defective in oriC segregation during [[category|Sporulation]] [pubmed|27489185]

The protein

Catalyzed reaction/ biological activity

regulates [SW|DNA replication] initiation by either inhibiting or activating the [SW|DNA replication] initiator protein [[protein|DnaA]] [Pubmed|21235642]; regulation of ''Spo0A'' expression [Pubmed|10852876]

ATP + H2O --> ADP + H+ + phosphate (according to UniProt)

The protein

Protein family

ParA family (with [[protein|FlhG]] and [[protein|MinD]], according to UniProt)

The protein

Paralogous protein(s)

[[this]]

The protein

Effectors of protein activity

[[protein|ParB]] inhibits [[protein|ParA]] dimerization and concomitant DNA-binding activity by stimulating [[protein|ParA]] ATPase activity [Pubmed|21235642]

The protein

Structure

[PDB|5U1G] [pubmed|28373206]

[PDB|5U1J] [pubmed|28373206]

The protein

[SW|Localization]

polar/ septal at the cell membrane [Pubmed|20566861]

polar localization depends on the proton motive force [Pubmed|20566861]

Expression and Regulation

Operons

[[this]]

Expression and Regulation

Other regulations

[[this]]

Biological materials

Mutant

BKE40970 ([[gene|parA]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE40970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGATGTCACCTACTTTCA, downstream forward: _UP4_GATTTAGCAAAGGAAGTGGC

BKK40970 ([[gene|parA]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK40970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGATGTCACCTACTTTCA, downstream forward: _UP4_GATTTAGCAAAGGAAGTGGC

labs

[SW|Heath Murray], Centre for Bacterial Cell Biology, Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/heath.murray homepage]

References

Reviews

20157337, 22934648, 26286503, 26706151, 28075389, 30863373

References

Original publications

15659156, 11532141, 19450516, 18854156, 10619015, 8866474, 12492861, 9701805, 12950914, 14651647, 19450516, 20566861, 21235642, 10852876, 14563866, 26253537, 22286949, 21911367, 27059541, 27489185, 28373206, 27489185, 31318889