2017-04-09 20:19:272025-05-13 13:35:20
description
ATPase, centromere-like function involved in forespore chromosome partitioning / negative regulation of [[category|Sporulation]] initiation
locus
BSU_40970
proteinLength
253
geneLength
762
function
forespore chromosome partitioning / negative regulation of [[category|Sporulation]] initiation
product
negative regulator of [[category|Sporulation]] initiation
essential
no
names
parA
soj
spo0JA
outlinks
bsupath
parA_4206397_4207158_-1
outlinks
uniprot
P37522
outlinks
subtilist
gene_detail BG10055
outlinks
bsu
BSU_40970
genomicContext
[[this]]
categories
[[this]]
Gene
Coordinates
4,206,397 4,207,158
Gene
Phenotypes of a mutant
defective in oriC segregation during [[category|Sporulation]] [pubmed|27489185]
The protein
Catalyzed reaction/ biological activity
regulates [SW|DNA replication] initiation by either inhibiting or activating the [SW|DNA replication] initiator protein [[protein|DnaA]] [Pubmed|21235642]; regulation of ''Spo0A'' expression [Pubmed|10852876]
ATP + H2O --> ADP + H+ + phosphate (according to UniProt)
The protein
Protein family
ParA family (with [[protein|FlhG]] and [[protein|MinD]], according to UniProt)
The protein
Paralogous protein(s)
[[this]]
The protein
Effectors of protein activity
[[protein|ParB]] inhibits [[protein|ParA]] dimerization and concomitant DNA-binding activity by stimulating [[protein|ParA]] ATPase activity [Pubmed|21235642]
The protein
Structure
[PDB|5U1G] [pubmed|28373206]
[PDB|5U1J] [pubmed|28373206]
The protein
[SW|Localization]
polar/ septal at the cell membrane [Pubmed|20566861]
polar localization depends on the proton motive force [Pubmed|20566861]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
BKE40970 ([[gene|parA]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE40970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGATGTCACCTACTTTCA, downstream forward: _UP4_GATTTAGCAAAGGAAGTGGC
BKK40970 ([[gene|parA]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK40970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGATGTCACCTACTTTCA, downstream forward: _UP4_GATTTAGCAAAGGAAGTGGC
labs
[SW|Heath Murray], Centre for Bacterial Cell Biology, Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/heath.murray homepage]
References
Reviews
References
Original publications